https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48347 Wed 15 Mar 2023 08:25:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49740 Tue 30 May 2023 14:40:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38579 in vitro lovastatin release from the alginate/chitosan/lovastatin nanoparticles under different conditions, including different alginate/chitosan ratios, different solution pH values and different lovastatin contents, were carried out by ultraviolet-visible spectroscopy. The rate of drug release from the nanoparticles is proportional to the increase in the solution pH and inversely proportional to the content of the loaded lovastatin. The drug release process is divided into two stages: a rapid stage over the first 10 hr, then the release becomes gradual and stable. The Korsmeyer-Peppas model is most suitable for the lovastatin release process from the alginate/chitosan/lovastatin nanoparticles in the first stage, and then the drug release complies with other models depending on solution pH in the slow release stage. In addition, the toxicity of alginate/chitosan/lovastatin (abbreviated ACL) nanoparticles was sufficiently low in mice in the acute toxicity test. The LD₅₀ of the drug was higher than 5000 mg/kg, while in the subchronic toxicity test with treatments of 100 mg/kg and 300 mg/kg ACL nanoparticles, there were no abnormal signs, mortality, or toxicity in general to the function or structure of the crucial organs. The results show that the ACL nanoparticles are safe in mice and that these composite nanoparticles might be useful as a new drug carrier.]]> Tue 09 Nov 2021 15:27:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:147 Thu 25 Jul 2013 09:09:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42198 Thu 25 Aug 2022 11:34:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33589 Thu 22 Nov 2018 13:41:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49463 Thu 18 May 2023 13:01:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29543 Sat 24 Mar 2018 07:33:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30547 Sat 24 Mar 2018 07:27:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3407 Sat 24 Mar 2018 07:21:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3485 Sat 24 Mar 2018 07:20:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24054 Sat 24 Mar 2018 07:09:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43431 2SO₄ to have better adsorption properties. On the contrary, modification of chitosan was carried out by acetaldehyde solution and acetic acid. Composite adsorbent was obtained as a mixture, comprising of modified cellulose and chitosan in a specific proportion (2g:1g). The surface characteristics of treated cellulose, chitosan and composite sample were evaluated by FTIR and SEM analysis. In addition, batch adsorption experiments were carried out to measure the influences of pH of the solution, adsorbent dosage and the initial concentration of metal ions. The maximum removal efficiency of Cr, Pb and Cd by composites was 56, 85 and 94%, respectively, at pH 4 when the metal concentration and adsorbent dosage were 60 ppm and 1.0 g L^-1. The maximum adsorption of Cr, Pb and Cd by composites was 55, 80 and 91 mg g^-1, respectively, at pH 4 when the metal concentration and adsorbent dosage were 120 ppm and 1.0 g L^-1.]]> Mon 19 Sep 2022 10:57:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54186 Mon 12 Feb 2024 13:54:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54114 Mon 05 Feb 2024 10:03:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33966 Carbopol®=Chitosan. Permeation of the drug was increased in presence of chitosan. The antimicrobial activity of MF against Staphylococcus aureus and Streptococcus mutans were found to be enhanced with the developed formulations. The highest antimicrobial activity was observed with the chitosan-based formulations, due to the synergic effect of chitosan itself. Our results showed that chitosan based formulation is a promising local delivery system for treatment of periodontal disease by increasing the effect of the drug due to its mucoadhesive and penetration enhancing effect as well its antimicrobial activity Furthermore, with these properties the developed formulations will provide reduced frequency of administration, which result in higher patient compliance.]]> Fri 25 Jan 2019 14:42:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38589 Fri 12 Nov 2021 15:59:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46157 2 g⁻¹). The optimized material exhibits a high surface area of 2278m² g⁻¹ and a pore volume of 1.00 cm³ g⁻¹. As high microporosity is beneficial for CO₂ adsorption, the prepared materials are employed as adsorbents for the capture of CO₂. The optimized sample displays excellent CO₂ uptakes at 0 °C/0.15 bar (1.1–1.8 mmol g⁻¹) and 0 °C/1 bar (4.3–6.1 mmol g⁻¹). The high surface area of the materials allows for high CO₂ uptakes at 0 °C/30 bar (17.3–22.0 mmol g⁻¹). The microporosity of these high surface area carbons is further decorated with strontium carbonate nanoparticles. The adsorption capacity per unit surface area is increased significantly upon the incorporation of the nanoparticles, revealing the role of the nanoparticles on the enhancement of the CO₂ adsorption capacity. A similar strategy could be extended for the fabrication of a series of microporous carbons derived from biomass for many applications including CO₂ capture.]]> Fri 11 Nov 2022 19:13:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49154 Fri 05 May 2023 12:34:58 AEST ]]>